Klf4 macrophage

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August undefined, 2024

WebMacrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human … WebAug 8, 2024 · The transcription factor Klf4 was found to cooperate with Stat6 to facilitate the macrophage M2 polarization 14. Further, Klf4 was recently identified as a direct MafB transcriptional target...

Frontiers Krüppel-Like Factors in Metabolic Homeostasis and ...

WebKLF4 may promote inflammation by mediating NF-κB-dependent inflammatory pathway such as in macrophages, esophageal epithelium and in chemically-induced acute colitis in … WebApr 8, 2024 · The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci. 2011;68:3121–31. Article CAS PubMed Google Scholar prince seven deadly sins

Distinct roles of KLF4 in mesenchymal cell subtypes during ... - Nature

WebOct 11, 2012 · We recently identified KLF4 as a regulator of macrophage subset specification; that is, KLF4 promotes M2 and inhibits M1 phenotype. Here, we provide evidence that KLF4-deficient macrophages exhibit enhanced proinflammatory activation and foam cell formation in response to oxidized lipids. WebJun 13, 2011 · Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators … WebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of … princes factory bradford

MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages …

Converting smooth muscle cells to macrophage-like cells with KLF4 …

WebJul 23, 2024 · Background. Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc … WebJun 4, 2015 · Macrophages are also derived from SMCs that undergo a phenotypic switch. Under the control of KLF4, the SMCs stop expressing marker proteins such as TAGLN, α-actin (ACTA2), and myosin heavy... prince sexuality lyricsWebApr 12, 2024 · These data suggest that KLF4 is a novel regulator of macrophage polarization. TAT- and Penetratin-linked Klf4 proteins can effectively replace viral Klf4 in … plenty of fish advertising

"WebApr 30, 2024 · As such, it is possible that kidney-derived CSF2 induces KLF4-dependent resident macrophage proliferation. Future studies will be needed to delineate the detailed mechanisms by which KLF4 regulates … " - Klf4 macrophage

Klf4 macrophage

Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

WebJun 11, 2024 · KLF4 appears to regulate this transition to a macrophage-like phenotype. Collectively then, whereas KLF4 in myeloid-lineage cells appears to be atheroprotective, KLF4 in SMCs is proatherogenic. These results point to differential functions of KLF members in different cell types in pathology. WebJan 1, 2024 · Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.

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WebOct 15, 2024 · Highlights. Intraperitoneal injection of tamoxifen in peanut oil increases autofluorescence of adipose tissue macrophages causing false identification as eYFP + cells.. Single-cell RNAseq using Myh11-Dre ERT2 tdTomato mice given oral tamoxifen identifies 8 perivascular cell dominated clusters, half of which are altered upon diet … WebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the …

WebOct 8, 2024 · The upregulation of macrophage makers is dependent on the transcription factor Klf4, but the exact mechanism for this activation of Klf4 has not previously been determined. 12 In this study, we demonstrate that cholesterol exposure activates all 3 pathways of the UPR and induces phenotypic switching primarily via the Perk-eIF2α-Atf4 … WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated …

WebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of immune checkpoints. Higher levels of CD8 + T cells and macrophage infiltration are associated with increased KLF4 expression in HCC TMA. WebKLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb.

WebDec 10, 2024 · In contrast to PDGFR-β + cells, KLF4 reduction in α-smooth muscle actin (SMA) + cells non-cell autonomously exacerbates lung fibrosis by inducing macrophage accumulation and pro-fibrotic...

WebJan 1, 2024 · KLF4 is a bifunctional transcription factor, and its promotional and inhibitory functions in atherosclerosis depend on the target genes and target cells. KLF4 has a … plenty of fish age limitWebApr 12, 2024 · Gain- and loss-of function study of KLF4 indicates that the DNMT1-mediated macrophage M1 activation is dependent on KLF4. Our data demonstrate a proatherogenic role for DNMT1 as a defining factor in macrophage inflammation both in vitro and in vivo. DNMT1 promotes macrophage M1 activation by suppressing KLF4 expression plenty of fish albany ny plenty of fis.comWebJan 1, 2024 · Under the influence of lipid peroxide, KLF4-deficient macrophages are easily transformed into foam cells. Experimental cell research has shown that KLF4-deficient macrophages exhibit enhanced foam cell formation and pro-inflammatory activation in response to lipid peroxide. plenty of fish albany waWebApr 13, 2024 · As an underlying anti-inflammatory factor, it has been reported that KLF4 can attenuate macrophages inflammation by inactivating NF-κB pathway and manage macrophages polarization, cells apoptosis and other biological activities [ 24 – 27 ]. plenty of fish age rangeWebDownload scientific diagram KLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb. princes factory cardiffWebMay 30, 2024 · The early upregulation of KLF4 in Mtb-infected macrophages, suggests that Mtb infection possibly impacts post-translational mechanisms of regulation of KLF4 as well. A post-transcriptional mechanism of upregulation of KLF4 linked to the downregulation of cellular miR-145 has been reported during infection of keratinocytes with human ... prince seymour hotel