Cisplatin toxicity review

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August undefined, 2024

WebOct 5, 2014 · Furthermore, combination therapies of cisplatin with other drugs have been highly considered to overcome drug-resistance and reduce toxicity. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the ... WebThe purpose of the review is to consolidate the reported risk of cardiotoxicity in patients treated with cisplatin based chemotherapy. Cisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in combination with other cardiotoxic agents.

Clinical comparative investigation of efficacy and toxicity of ...

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … WebJun 1, 2016 · The carboplatin-docetaxel arm had a more favourable toxicity profile and a significant number of patients withdrew from the cisplatin-docetaxel doublet due to grade 3–4 emesis ( Greco et al., 2000 ). Other studies have observed the efficacy and tolerability of platinum-gemcitabine regimens in CUP. k shift registration

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was … WebThe cytotoxic activity in human cancer cell lines against colon adenocarcinoma (HCT-15), mammary adenocarcinoma (MCF-7), and lung adenocarcinoma (SKLU-1) was found comparable ((DAC) 2 Mg), or ca. 2-fold higher ((DAC) 2 Zn) than cisplatin. The acute toxicity assays indicate class 5 toxicity, according to the Organization for Economic Co ... WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which … ks high index prg dig+ar

Adverse Cardiac Manifestations of Cisplatin - A Review

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). … WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. ksh if文 -aWebReview on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin Sara A. Aldossary Clinical pharmacy college, king faisal university Alhassa … ks high school football playoff bracket

"WebSep 27, 2024 · We conducted a systematic review to identify which genetic variants consistently associated with cisplatin-induced nephrotoxicity in oncology patients and assessed whether there are genetic variants that might be clinically relevant to guide cisplatin treatment. Methods " - Cisplatin toxicity review

Cisplatin toxicity review

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

WebAug 5, 2024 · Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicit … WebFeb 22, 2024 · Cisplatin is a known nephrotoxic agent, so reducing its concentration to get a similar toxicity profile in NSCLC cells is advantageous. For the two normal lung cell lines ( Figure 4 A,B), while the Lipo-PEITC-CDDP caused the lowest survival percentages, 59.0 ± 15.7% and 71.5 ± 11.0% for WI-38 and BEAS-2B, respectively, the cytotoxic effect of ...

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WebMethods: This article examined a collection of studies suggesting that CYP450 enzymes may influence cisplatin toxicity. We performed a narrative mini-review. Results: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11. WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral …

WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in … WebDec 12, 2024 · This systematic review underlines some practice principles for cisplatin-induced nephrotoxicity. Therefore, at a cisplatin dosage of less than 50 mg/m 2, both short-duration and low volume hydration with normal saline prevent nephrotoxicity, as well as outpatient administration.

WebThe introduction of cisplatin to the clinic highlighted the hazards that follow failure to understand the renal complications of cytotoxic agents. 28 Effectively overcoming this principal toxicity of cisplatin has allowed … WebNov 26, 2024 · This review is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin, which belong to different CT groups—alkylating agents, antimetabolites and antitumor antibiotics, respectively. ... Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy …

WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects.

Webcisplatin-induced nephrotoxicity has not been well studied. Intracellular Events that Damage Renal Cells The in vivo mechanisms of cisplatin nephrotoxic-ity are complex and involve … ks high school athletic assnWebdose-dependent renal toxicity. Methods: We reviewed clinical and experimental literature on cisplatin nephro-toxicity to identify new information on the mechanism of injury and potential approaches to prevention and/or treatment. Results: Unbound cisplatin is freely filtered at the glomerulus and taken up into renal tubular cells ks highway patrol logWebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative … ks high school playoffsWebThe RRs were 22% and 22%, respectively. One-year survival rates were 31% and 36%, respectively. What we have researched was Abraxane plus cisplatin and gemcitabine plus cisplatin, and their RRs were higher than ECOG 1594 clinical trials. The RR between the TP group and GP group also had significant difference. ks highway 50 camerasWebCisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. The current study presents a … ks highway patrol crash logsWebIntroduction: Cisplatin is an effective chemotherapeutic agent commonly used in the treatment of malignant tumours, but ototoxicity is a significant side effect. Objectives: To discuss the mechanisms of cisplatin ototoxicity and subsequent cell death, and to present the results of experimental studies. Material and methods: We conducted a systematic … ks highway camerasWebThe RRs were 22% and 22%, respectively. One-year survival rates were 31% and 36%, respectively. What we have researched was Abraxane plus cisplatin and gemcitabine … ks highway patrol.org