Adipocyte lipase

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August undefined, 2024

WebNov 22, 2024 · The discovery of adipose triglyceride lipase (ATGL) as a triglyceride lipase provided a heightened understanding of the mechanisms governing mobilization of fat … WebDec 1, 2002 · Hormone-sensitive lipase (HSL) is presumed to be essential for lipolysis, which is defined as the mobilization of free fatty acids from adipocytes. In the present study, we investigated the effects of various lipolytic hormones on the lipolysis in adipocytes derived from mouse embryonic fibroblasts (MEF adipocytes) prepared from HSL …

The role of adipose triglyceride lipase in lipid and glucose ...

WebSep 5, 2008 · Adipocytes and adipose tissue produce a wide range of hormones and cytokines involved in glucose metabolism (e.g. adiponectin, resistin), lipid metabolism (e.g. cholesteryl ester transfer protein, CETP), inflammation (e.g. TNF-α, IL-6), coagulation (PAI-1), blood pressure (e.g. angiotensinogen, angiotensin II), and feeding behaviour (leptin) … WebMay 11, 1999 · Hormone-sensitive lipase (HSL) is a cytosolic neutral lipase that functions as the rate-limiting enzyme for the mobilization of free fatty acids in adipose tissue. By using the yeast two-hybrid sys... feet in the air

Lysosomal acid lipase promotes endothelial proliferation in cold ...

WebGlucagon receptor expression has been reported in rat adipocytes (Svoboda et al., 1994; ... Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on … WebHormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes. HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. WebAdipose tissue lipolysis is the catabolic process whereby stored triacylglycerol (TAG) is broken down by lipases into fatty acids and glycerol. Here, we review recent insights … feet internal bleeding

Lipid and glucose metabolism in white adipocytes: …

A lipase-independent pathway of lipid release and …

WebMar 29, 2024 · Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL). Lipoprotein … WebA lipase-independent pathwayof lipid release and immune modulation byadipocytes Stephen E. Flaherty III 1*, Ambar Grijalva1*, Xiaoyuan Xu , Eleanore Ables , Alireza Nomani2, Anthony W. Ferrante Jr.1† To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. feet in the air head on the groundWebMar 1, 2024 · We found that adipocytes release exosome-sized, lipid-filled vesicles (AdExos) that become a source of lipid for local macrophages. Adipose tissue from lean … define scapegoating theory

"WebMar 29, 2024 · Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating … " - Adipocyte lipase

Adipocyte lipase

Adipocyte hormone-sensitive lipase: a major regulator of lipid ...

WebFeb 1, 2002 · Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in the mobilization of fatty acids from adipose tissue, thus determining the supply of energy substrates in the body. HSL mRNA was positively regulated by glucose in … WebJan 1, 2006 · Adipose triglyceride lipase (ATGL) is a recently described adipose-enriched protein with triglyceride-specific lipase activity. ATGL shares the greatest sequence …

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WebNov 2, 2024 · Adipocytes, which respond to nutritional inputs by orchestrating lipid mobilization and fatty acid fluxes across the body, are essential to maintain metabolic health. Adipose tissue (AT) is equipped with highly regulated cytoplasmic lipases that become activated at the LD surface to fine tune lipid release ( 9, 10 ).

WebA novel adipocyte triglyceride lipase has been recently reported, designated as adipose triglyceride lipase (ATGL) or desnutrin in mice and calcium-independent phospholipase A 2 (iPLA 2)ζ in humans . ATGL shares the greatest homology with adiponutrin, thus raising the possibility that these two molecules share function and/or regulation. WebApr 11, 2024 · Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte sensitivity to insulin to restrain lipid accrual. This adipokine may modulate the production of cytokines that could diminish insulin sensitivity, particularly in visceral adipose tissue. To explore this possibility, we examined the effects of chronic central …

WebMay 5, 2013 · Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acids via lipoprotein lipase (LpL). To determine how LpL affects the … WebAdipocyte hormone-sensitive lipase: a major regulator of lipid metabolism Published online by Cambridge University Press: 11 October 2007 Dominique Langin , Cecilia Holm and …

WebAbreviaturas 229 GSK-3: glicógeno sintasa quinasa 3 GSV: vesículas de almacenamiento de GLUT4 GTPasas: proteínas que hidrolizan GTP HSL: lipasa sensible a hormonas (hormone sensible lipase) IBMX: metil-isobutilxantina IR: receptor de insulina KO: knockout.Un organismo knockout es un organismo genéticamente modificado portador …

WebOct 30, 2007 · A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. feet in the air and your head on the groundWebMar 10, 2024 · Modulation of adipocyte lipolysis represents an attractive approach to treat metabolic diseases. Lipolysis mainly depends on two enzymes: adipose triglyceride lipase and hormone-sensitive lipase (HSL). Here, we investigated the short- and long-term impact of adipocyte HSL on energy homeostasis using … feet in the air head on the ground lyricsWebMay 28, 2014 · Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation are the best known. Initially, hormone-sensitive lipase (HSL) was thought to be the rate-limiting enzyme of the first lipolytic step, while we now know that adipocyte TAG lipase is the key enzyme for lipolysis initiation. define scant in bakingWebNov 1, 2005 · The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase … feet in the air and head on the ground• Kraemer FB, Shen WJ (October 2002). "Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis". Journal of Lipid Research. 43 (10): 1585–94. doi:10.1194/jlr.R200009-JLR200. PMID 12364542. • Langfort J, Donsmark M, Ploug T, Holm C, Galbo H (August 2003). "Hormone-sensitive lipase in skeletal muscle: regulatory mechanisms". Acta Physiologica Scandinavica. 178 (4): 397–403. doi:10.1046/j.1365-201X.2003.01155.x. PMID 1286… feet in the air poseWebFeb 10, 2006 · Studies have provided evidence that HSL, though possessing triacylglycerol lipase activity, appears to be the rate-limiting enzyme for cholesteryl ester and diacylglycerol hydrolysis in adipose tissue and is essential for complete hormone stimulated lipolysis, but other triacylglycerol lipases are important in mediating triacylglycerol hydrolysis … define scarfing downWebJul 4, 2024 · Lipoprotein lipase deficiency is a genetic disorder with an autosomal recessive pattern of inheritance. It usually presents in childhood and is characterized by severe hypertriglyceridemia and … feet in the bathtub